Endocrine Abstracts

Background: A recent study by the author suggests up to 73% of growth hormone (GH) secreting pituitary adenomas produce multiple hormones on histological analysis and 16% immunostain positive for TSH. We report the case of an acromegalic patient with a plurihormonal adenoma where diagnosis of thyrotoxicosis was made several years post-hypophysectomyCase history: Mr JT was diagnosed with acromegaly at the age of 59 having been noted to have acromegalic ph...

History: A 62-year-old female presented to casualty with headache and hyponatraemia (Na 113 mmol/l) on the background of nausea and vomiting, preceded by sudden onset occipital headache 10 days previously. Other routine blood results were unremarkable apart from K 3.4 mmol/l.Biochemical investigations were consistent with SIADH. (Serum osmolality 233 mos/kg, urine 641 mos/kg, urinary Na 43 mmol/l). Early morning cortisol on admission was 828 nmol/l.<...

Clinical practice suggests that low dose steroid treatment delivered locally to the site of action may rarely lead to disturbances of the hypothalamic-pituitary-adrenal axis. We present three clinical examples:Case 1: A 72 yr old man with a history of severe sinusitis was referred because of three episodes of profound anorexia, vomiting and proximal muscle weakness which coincided with discontinuing his Betnesol (betamethasone sodium phosphate 0.1%) nose...

Introduction: Studies have suggested that PCOS is associated with increased cardiovascular (CVS) risk. The mechanisms that may contribute to increased CVS susceptibility include endothelial dysfunction, vascular inflammation and atherothrombosis.Aim: To compare CVS risk profiles in women with PCOS and healthy age and weight matched controls using novel biochemical and biophysical markers of these pathological processes.Method: Fo...